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Immunoelectron Microscopic Localization Of Neural Cell Adhesion Molecules L1, N
After a penetrating lesion in the central nervous system, astrocytes enlarge, divide, and take part in creating an setting that adversely affects neuronal regeneration. We have recently shown that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals were lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one side, the lesions have been concomitantly infused with N-CAM or with one of many N-CAM-related molecules. As a management, a peptide of the identical composition because the N-CAM decapeptide however of random sequence was infused on the contralateral side of the brain. The inhibition was biggest in the cortical lesion sites (approximately 50%) and was less pronounced within the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a considerably smaller population of dividing astrocytes than the sites on the opposite aspect.
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Del Rio JA, Soriano E. Immunocytochemical detection of 5′-bromodeoxyuridine incorporation in the central nervous system of the mouse. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The position of mononuclear phagocytes in wound therapeutic after traumatic harm to adult mammalian mind. Smith GM, Rutishauser U, Silver J, Miller RH. Maturation of astrocytes in vitro alters the extent and molecular foundation of neurite outgrowth. Full text is out there as a scanned copy of the unique print model. Get a printable copy of the complete article (1.6M), or click on a page image below to browse page by web page. Links to PubMed are additionally obtainable for Selected References. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG within the creating and adult optic nerve of mice.
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